1/14/2024 0 Comments Indian burn left itchSeveral conditions affecting the peripheral nervous system are associated with neuropathic itch ( Table 1). However, epidemiological studies investigating the prevalence and incidence of neuropathic itch are still missing.ĭamage at any site of the somatosensory system, including peripherally nerve fibers, nerve plexuses and ganglia, and centrally the spinal cord, brainstem, thalamus or cortex, may lead to neuropathic itch ( 3). It is estimated that 8% of chronic itch cases have a neuropathic origin ( 2). The International Forum for the Study of Itch (IFSI) defines neuropathic itch as itch occurring due to an injury of neurons of the peripheral or central nervous system ( 1). This review article provides a comprehensive overview of the diagnostic work-up recommended for patients with neuropathic itch. Functional assessments such as quantitative sensory testing, nerve conduction studies, evoked potentials, or microneurography may be considered in particular cases. Complementary diagnostic exams, especially laboratory tests, determination of the intraepidermal nerve fiber density via a skin biopsy and radiological examinations may be indicated to confirm the diagnosis of neuropathic itch and to identify underlying etiological factors. A detailed medical history, especially in regard to the itch, and a comprehensive physical examination are relevant to detect characteristic signs and symptoms of neuropathic itch and to rule out other possible causes for chronic itch. Due to the complex nature of neuropathic itch, particularly concerning its clinical presentation and possible etiological factors, diagnostic work-up of this condition is challenging. Several entities, including metabolic, neurodegenerative, orthopedic, infectious, autoimmune, malignant, and iatrogenic conditions, may affect the somatosensory system and induce neuropathic itch. Neuropathic itch occurs due to damage of neurons of the peripheral or central nervous system. Department of Dermatology and Center for Chronic Pruritus, University Hospital Münster, Münster, Germany. Manuel Pedro Pereira *, Henning Wiegmann, Konstantin Agelopoulos and Sonja Ständer
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